Linking the Clock to Metabolism

Welcome to TiMet

TiMet assembles world leaders in experimental and theoretical plant systems biology to advance understanding of the regulatory interactions between the circadian clock and plant metabolism, and their emergent effects on whole-plant growth and productivity.

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RT @A_J_Millar: Cross-species data + model analysis from @TiMet_project @CBSEd shows light and loops give flexible biological clocks http:/…

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TiMet - Linking the Clock to Metabolism is a Collaborative Project (Grant Agreement 245143) funded by the European Commission FP7, in response to call FP7-KBBE-2009-3.



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News

TiMet is part of an expanding network of plant systems biology projects around the world. We aim to be a useful contact point for news, knowledge exchange and discussion. Please join the conversation!

27.09.2013 | Sarah Hodge

Horizons for Social Sciences and Humanities: The Vilnius Declaration

Earlier this week (September 23-24) the Lithuanian Presidency of the EU Council held an international conference on the “Horizons for Social Sciences and Humanities“ in Vilnius. Participants discussed the ways to address the most pressing global challenges and to define the roles of social sciences

02.05.2013 | Sarah Hodge

Sharing knowledge from FP7 projects in plant systems biology

As a prelude to our recent Annual Meeting, held this year at The Centre for Research in Agricultural Genomics (CRAG) in Barcelona, TiMet hosted a workshop attended by the leaders of eight other projects and  nine industry stakeholders, all involved in EU FP7 projects funded under the KBBE (knowledge

Research

Plant
Growth/Development

TiMet is advancing understanding of how plants regulate the use of carbon for growth and productivity. We combine quantitative biology and computational modelling to explore the interaction of the circadian clock and key metabolic pathways that regulate leaf and root growth in the model plant Arabidopsis thaliana. Our work will contribute to the construction of multi-scale models of plant growth that can predict performance in response to environmental cues.

Research

Starch
Metabolism

Plants capture energy and assimilate carbon – via photosynthesis – in the light, but cannot do so in the dark.  They buffer these daily fluctuations in their carbon budget by storing some of the assimilated carbon as starch in their leaves and by utilising it as a carbon supply during the night.

Research

Isoprenoid
Metabolism

Isoprenoids represent a diverse group of plant metabolites, with a host of structural and functional roles that are critical to plant growth, development and survival.

Research

Circadian
Clocks

Plants must orchestrate the accumulation and utilisation of photosynthetic products over the daily cycle to avoid periods of starvation, and thus optimise growth rates. Discovering the mechanism by which the circadian clock exercises control over metabolism is essential if we are to find new ways to enhance plant productivity. TiMet scientists are developing new computational models of the gene regulatory networks that operate in the Arabidopsis thaliana circadian clock.

Research

Computational
Modeling

Rapid progress in the field of theoretical systems biology underpins Timet’s efforts to model pathways and networks. Integrating different approaches is important to develop consistent theoretical descriptions encompassing various scales of biological information.

Resources

Data
Infrastructure

TiMet’s data infrastructure supports the biological research data workflow by facilitating cross-domain queries for all data, metadata, and associated models. The TiMetDB data warehouse architecture builds on a design implemented for the EU Framework 6 AGRON-OMICS project.

18.10.2012

Agron-omics Leaf Database

TiMet users have access to the Agron-omics Leaf Database, the data integration and data sharing portal

18.10.2012

BioDare

Many datasets of importance to TiMet are deposited in the BioDare Biological Data Repository, which

18.10.2012

PlaSMo

PlaSMo (Plant System Biology Modelling) provides TiMet with a central resource of current plant based

18.10.2012

TiMetDB

TiMetDB (login required) is the central database, analysis and modelling platform of the consortium. 

Resources

Computational
Models

Integrating mathematical models of biochemical and gene networks can link cell-level regulation to an emergent property (plant growth) at whole organism level. Such multi-scale modelling is a major goal for plant systems biology.

Resources

Publications

New knowledge inspires collaboration, prioritises experimental effort, provides new hypotheses, and informs experimental designs.

About TiMet

People

TiMet assembles world leaders in experimental and theoretical plant systems biology to advance understanding of the regulatory interactions between the circadian clock and plant metabolism, and their emergent effects on whole-plant growth and productivity.

13.12.2012

Sam Zeeman

Samuel C Zeeman is Professor of Plant Biochemistry at ETH Zurich, Switzerland. He is an expert in

26.10.2012

Dirk Husmeier

Dirk Husmeier holds a Chair in Statistics in the School of Mathematics and Statistics at the University

24.10.2012

Oliver Ebenhoeh

Oliver Ebenhoeh is Reader in Systems Biology,  a joint position of the Institute for Complex Systems

24.10.2012

Mark Stitt

Prof. Mark Stitt and his group at the Max Planck Institute of Molecular Plant Physiology (MPIMP) 

24.10.2012

Wilhelm Gruissem

Wilhelm Gruissem, Professor of Plant Biotechnology at ETH Zurich, Switzerland, is a world expert in

24.10.2012

Alison Smith

Alison Smith is Head of the Department of Metabolic Biology at the John Innes Centre in Norwich,

24.10.2012

Andrew Millar

Andrew Millar holds a Chair of Systems Biology in SynthSys at the University of Edinburgh, UK. He

About TiMet

Partners

The TiMet consortium brings together leading centres for the emerging discipline of Systems Biology, at a European and world scale.

About TiMet

Connections

TiMet is one of several  EU-funded projects that collectively contribute to Europe’s  knowledge-based bio-economy (KBBE) by bringing together science, industry and other stakeholders to generate and exploit new knowledge related to plant and crop growth and productivity.

13.12.2012

3 to 4

If photorespiration could be reduced in current C3 crops, or if they could be converted to use C4 photosynthesis

26.10.2012

RootoPower

Understanding of root-to-shoot signalling and source-sink relationships; Exploitation of natural genetic

26.10.2012

EURoot

Making use of joint phenotyping and modelling platforms, EURoot's objective is to enhance the cereal

26.10.2012

Abstress

Resistance of crops to combined abiotic and  biotic stress (legumes).

26.10.2012

Drops

Developing  novel methods and strategies for genetic yield  improvement under  dry environments and

26.10.2012

AenEAs

Impact of environmental conditions on epigenetic states (maize).

26.10.2012

Recbreed

Genetic and molecular tools for plant breeding (tomato and maize).

26.10.2012

EUSol

Genes underlying important plant traits (Solanaceae).

26.10.2012

Metapro

Secondary metabolites / isoprenoids  (Solanaceae).

26.10.2012

AGRON-OMICS

Molecular components driving growth.

About TiMet

Contact

TiMet is part of an expanding network of plant systems biology projects  around the world. We aim to be a useful contact point for knowledge exchange and discussion